منابع مشابه
TRIM-NHL Proteins Take on miRNA Regulation
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
متن کاملTRIM proteins: New players in virus-induced autophagy
Autophagy is an evolutionarily conserved and intricately regulated cellular process in which damaged or aggregated proteins, organelles, and pathogen-derived components are engulfed by double-membrane structures, termed autophagosomes, and targeted for lysosomal degradation [1]. The autophagic process consists of distinct phases that include nucleation, autophagosome formation, selection of car...
متن کاملTumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK
MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.
متن کاملFunctional interactions between ubiquitin E2 enzymes and TRIM proteins.
The TRIM (tripartite motif) family of proteins is characterized by the presence of the tripartite motif module, composed of a RING domain, one or two B-box domains and a coiled-coil region. TRIM proteins are involved in many cellular processes and represent the largest subfamily of RING-containing putative ubiquitin E3 ligases. Whereas their role as E3 ubiquitin ligases has been presumed, and i...
متن کاملInvestigation of Network of Proteins Effective in Esophageal, Gastric and Colon Cancers and Determination of Key Common Proteins Using In Silico Method
Introduction: The prevalence of gastrointestinal cancers, especially gastric and colorectal cancers, is increasing. Gastric cancer is the most common gastrointestinal cancer in Iran and the age of esophageal and colon cancers onset has decreased in Iran. Therefore, it is important to study the factors and proteins involved in these cancers. Use of computational tools is an effective way to stud...
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ژورنال
عنوان ژورنال: Journal of Cell Communication and Signaling
سال: 2017
ISSN: 1873-9601,1873-961X
DOI: 10.1007/s12079-017-0423-5